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A Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.

Recruitingn/aAges 18 Years - anyAllCentre Hospitalier Universitaire Dijon
NCT07695545 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality. Their pathophysiology is based on complex mechanisms involving inflammatory and metabolic processes, as well as alterations in mitochondrial function. The presence of a bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) significantly influences the progression and severity of aneurysms. Bicuspid aortic valve (BAV) patients often develop aortic aneurysms earlier, as early as age 40-50, whereas tricuspid aortic valve (TAV) patients generally present with a degenerative condition that appears later (after age 50). The objective of this study is to compare the inflammatory, metabolic, and transcriptomic signatures of myeloid cells and total aortic tissue between BAV and TAV patients. These analyses will help identify specific molecular mechanis

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📋 Eligibility rules (as published)
Inclusion Criteria: * Individuals who have given their consent * Patients with an ascending aortic aneurysm for which surgical replacement is indicated * Age \> 18 years * Scheduled surgery * Preoperative ultrasound confirmation of the heart valve architecture (bicuspid or tricuspid valve) Exclusion Criteria: * A person subject to a legal protective measure (guardianship, conservatorship) * A person subject to a judicial safeguard measure - A pregnant woman, a woman in labor, or a breastfeeding woman * Adults who are legally incapacitated or unable to give consent * Emergency surgical procedures * Patients with uncontrolled inflammatory or autoimmune conditions * Patients with a history of recent acute infection (within the last 3 months or still undergoing treatment) * Patients with a condition requiring immunosuppressants - Patients with a confirmed or suspected genetic aneurysm (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.) * Patients with a history of cardiac surgery
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What it tests

  • Additional blood samples
  • Collection of discarded ascending aortic tissue
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Where

1 site
Chu Dijon Bourgogne
Dijon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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