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ULTIMATE Study (Carotid Ultrasound Vs CT Coronary Calcium Scoring to Reclassify Symptomatic Patients With Chronic Coronary Syndrome)

RecruitingNAAges 18 Years - anyAllLondon North West Healthcare NHS Trust
NCT07696533 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

* Chest pain is one of the most common symptoms of heart disease. This could be due to narrowing in heart's blood vessels, which needs to be investigated. * Currently, people with a low risk of narrowing of heart vessels usually have a CT scan of the heart first. This scan is good at identifying those who do not have significant narrowing. However, the scan has some drawbacks, such as exposure to a small amount of radiation. * We are exploring if ultrasound of the neck vessels might give us similar kind of information as the CT scan. * You will be asked to attend the hospital for one visit to have an ultrasound scan of your neck. * The findings of your neck vessels will be compared with the CT scan of your heart vessels to see if there is a similarity.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age \> 18 years old 2. Symptomatic patients with suspected CCS, judged by the clinician to require CTCA with CAC scoring, for the diagnosis of CAD 3. Have a RF-CL 5-15%, as calculated using ESC guidelines 4. Able to give informed consent to participate in the study and its follow up Exclusion Criteria: 1. Age \<18 years old 2. Diagnosed ACS requiring hospitalization or urgent or emergent testing 3. Known CAD with prior MI, PCI, CABG or any angiographic evidence of CAD (≥50% lesion in a major epicardial vessel) 4. History of previous stroke or known peripheral vascular disease 5. Known significant cardiac congenital abnormalities 6. Pregnancy 7. Life expectancy \< 1 years 8. Unable to provide written informed consent
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What it tests

  • Carotid Ultrasound
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Where

1 site
Northwick Park Hospital
Harrow, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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