Anti-inflammatory Effects of Curcumin, Ginger and Piperine Supplementation in Ultra-trail Runners: a Double-blind Randomized Placebo-controlled Trial

Inclusion Criteria: * Age ≥ 18 years at inclusion * Registered for "La Diagonale des Fous" (Grand Raid de La Réunion, 175 km, 2026 edition) * Free, informed, signed consent obtained prior to any study-related procedure * Availability to participate in the full protocol, including preliminary consultations and biological sampling at all time points (T0 to T3) * Affiliated with or beneficiary of a social security scheme * Ability to understand and follow study instructions (sufficient French language level, or assistance available) Exclusion Criteria: * Regular NSAID use in the 30 days prior to inclusion, defined as intake at least 3 days/week for at least 2 consecutive weeks, or ongoing treatment at the time of inclusion * Regular use of curcumin-containing supplements or "9-5-1"-type preparations in the 30 days prior to inclusion, defined as intake at least 3 days/week for at least 2 consecutive weeks * Taking anticoagulant treatment * History of hepatic, biliary, or pancreatic disease, including: gallstones, cholestasis, acute or chronic hepatitis, cirrhosis * Known allergy or documented hypersensitivity to any capsule component: turmeric, curcumin, ginger, black pepper, maltodextrin, or hydroxypropylmethylcellulose (HPMC) * Chronic inflammatory joint disease (e.g., rheumatoid arthritis, spondyloarthritis) under active specific treatment * Pregnancy or breastfeeding * Participation in another biomedical study involving a therapeutic intervention within the 30 days prior to inclusion * Severe cognitive or psychiatric impairment preventing understanding of the protocol or completion of questionnaires * Patient under guardianship/curatorship or subject to a legal protection order