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Multicenter Cardiac Decision Impact Study in People With Breast Cancer

RecruitingNAAges 35 Years - anyAllUMC Utrecht
NCT07703033 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Breast cancer is the most common cancer in women, and advances in early detection and treatment have led to steadily improved survival rates. Today, nearly 80% of breast cancer survivors are over 50 years of age. With longer survival, comes a greater burden of chronic disease, particularly cardiovascular disease (CVD), which is more common in breast cancer survivors than in the general population. This elevated risk is driven by treatment-related effects, such as chemotherapy- and radiotherapy-induced cardiotoxicity, metabolic changes including (therapy-associated) weight gain, and shared lifestyle risk factors such as obesity and physical inactivity. In routine clinical care, approximately 65% of breast cancer patients undergo local radiotherapy (RT) and will receive a planning computed tomography (CT) scan. These scans, while intended for RT planning, also capture valuable

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📋 Eligibility rules (as published)
Inclusion Criteria: * diagnosed with breast cancer or ductal carcinoma in situ * Planned for radiotherapy * From 35 years of age onwards Exclusion Criteria: * Pregnancy * Breastfeeding
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What it tests

  • Measuring coronary artery calcifications (Agatston score) using routine radiotherapy planning CT scans and communicating the associated risk of cardiovascular disease to the patient.
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Where

5 sites
RegionH
Copenhagen, Denmark
LMU University Hospital
München, Germany
Amsterdam University Medical Center
Amsterdam, Netherlands
St. Antonius Hospital
Utrecht, Netherlands
Champalimaud Foundation
Lisbon, Portugal
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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