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More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)

RecruitingNAAges 3 Years - anyAllUniversity of Erlangen-Nürnberg Medical School
NCT07705178 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.

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📋 Eligibility rules (as published)
Control Group: Inclusion Criteria: * no cancer diagnosis * no lung diseases * no vascular diseases * No subjective reduction in physical performance * age \>/= 18 years Exclusion Criteria: * Pregnancy, Lactation * Known pleural or pericardial effusion * Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure) * Marked thoracic deformities/malformations * Previous lung surgery * Injuries that do not allow physical stress diagnostics * Rejection of MRI imaging * General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.) Survivors of ALL: Inclusion Criteria: * Completed therapy for ALL * age \>/= 3 years Exclusion Criteria: * Pregnancy, Lactation * Known pleural or pericardial effusion * Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure) * Marked thoracic deformities/malformations * Previous lung surgery * Injuries that do not allow physical stress diagnostics * Rejection of MRI imaging * General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.) Survivors of Lymphoma: Inclusion Criteria: * Completed therapy for lymphoma * age \>/= 3 years Exclusion Criteria: * Pregnancy, Lactation * Known pleural or pericardial effusion * Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure) * Marked thoracic deformities/malformations * Previous lung surgery * Injuries that do not allow physical stress diagnostics * Rejection of MRI imaging * General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)
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What it tests

  • QOL assessment, Neuropsychological
  • Spirometry
  • DLCO measurement
  • Echocardioraphy
  • MRI
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Where

1 site
Department of Pediatrics and Adolescent Medicine
Erlangen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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