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The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion

RecruitingNAAges 18 Years - anyAllUniversidad Autonoma de Nuevo Leon
NCT07705269 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are hospitalized due to severe fluid overload (congestion). When patients with End-Stage Renal Disease (ESRD) on chronic hemodialysis are admitted to the hospital with excess fluid, doctors often need to remove this fluid quickly to relieve symptoms like severe shortness of breath. However, traditional guidelines recommend conservative fluid removal rates-called ultrafiltration (UF) rates-between 10 and 13 mL/kg/h to prevent sudden drops in blood pressure (intradialytic hypotension). Despite these guidelines, doctors in real-world hospital settings frequently use higher rates to provide urgent relief, though this practice lacks strong scientific backing. This study

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults over 18 years old with End-Stage Renal Disease on hemodialysis for at least 3 months. * Admitted to the hospital requiring mechanical fluid removal for acute fluid overload (first in-hospital session). * Clear ultrasound evidence of severe intravascular congestion (such as diffuse B-lines in the lungs or altered VExUS vascular flow patterns). * Hemodynamically stable with a baseline blood pressure of at least 120/80 mmHg. Exclusion Criteria: * Baseline low blood pressure (\<100/60 mmHg) or active shock (cardiogenic, septic, or distributive). * Acute coronary syndrome (heart attack), severe heart valve disease, or severe fluid around the heart. * Known chronic lung disease. * Pregnancy.
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What it tests

  • High-rate ultrafiltration
  • Standard fluid removal
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Where

1 site
Hospital Universitario "Dr. José E. González"
Monterrey, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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