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Plasma Exchange in Children With Severe Sepsis and Septic Shock

RecruitingNAAges 1 Month - 18 YearsAllMenoufia University
NCT07706413 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone. The study population will be divided into two groups, the first group will receive standard sepsis management plus therapeutic plasma exchange and the second one will receive the standard sepsis management alone . Then we will assess the effect of TPE on : Severity of organ dysfunction (pSOFA score) , duration of vasopressor support , length of PICU stay, time to hemodynamic stabilization , and on inflammatory and coagulation biomarkers

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. From one month to 18 years. 2. With an established diagnosis of severe sepsis or septic shock according to international pediatric sepsis definitions. Exclusion Criteria: 1. Known congenital bleeding disorders and severe uncontrolled hemorrhage. 2. End-stage chronic illness with expected survival \< 3 months. 3. Previous plasma exchange during the same admission. 4. Contraindications to central venous catheterization.
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What it tests

  • Plasma exchange (PE)
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Where

1 site
Menoufia university hospital, Pediatric intensive care unit
Shibฤซn al Kawm, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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