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Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations

RecruitingNAAges 5 Years - anyAllUwemedimo Friday Ekpo
NCT07707817 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Neglected Tropical Diseases (NTDs) are among the most common groups of diseases affecting over one billion people globally and are disproportionately concentrated in remote, underserved, and marginalized communities. Efforts toward NTD elimination have largely relied on preventive chemotherapy (PC), large-scale distribution of free, safe, and effective medicines to at-risk populations. One major challenge threatening elimination efforts is the poor participation of mobile and migrant populations (MMPs) in treatment programs. Despite this gap, few studies have explored strategies to improve access among these underserved populations. This study aims to determine the burden of NTDs among MMPs and explore strategies for expanding access to preventive chemotherapy through social and occupational networks using community mapping and participatory action research approaches in Nigeria. This

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📋 Eligibility rules (as published)
Inclusion Criteria: Participants will be eligible for inclusion if they: 1. Are children aged 5-14 years or adult heads of households residing in households identified as belonging to mobile or migrant populations. 2. Reside permanently or semi-permanently within the study communities 3. Have missed one or more previous rounds of onchocerciasis and/or lymphatic filariasis MDA. 4. Are willing to provide the required biological specimens and participate in interviews, surveys, and participatory workshops or discussions as required by the study protocol. 5. Provide informed consent or assent with parental/guardian consent where applicable for minors. Exclusion Criteria: Participants will be excluded if they: 1. Are temporary visitors without meaningful residence in the study communities. 2. Do not belong to the identified mobile or migrant populations targeted by the study. 3. Are unable or unwilling to provide the required biological specimens or participate in study procedures. 4. Decline informed consent or assent, or whose parent or guardian declines consent for participation. 5. Are severely ill or have medical conditions that, in the opinion of study personnel, would make participation unsafe or inappropriate.
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What it tests

  • Modified Mass Administration of Medicines Strategy
  • Albendazole 400 mg
  • Praziquantel 40 mg/kg
  • Ivermectin
  • Ivermectin + albendazole
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Where

1 site
Recruitment is done at the Household level in selected communities
Ondo, Nigeria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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