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Quantitative Myocardial Perfusion Imaging Assessment by SPECT/CT

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Régional d'Orléans
NCT07708805 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Myocardial perfusion single-photon emission computed tomography (SPECT) is a well-established functional imaging technique for the assessment of coronary artery disease. Recent developments in cadmium-zinc-telluride (CZT) camera technology have enabled significant reductions in acquisition time while improving image quality. Positron emission tomography (PET) myocardial imaging remains the reference standard for the quantitative assessment of myocardial blood flow (MBF) and myocardial flow reserve (MFR); however, its use is limited by high costs and restricted availability. This exploratory study aims to evaluate the feasibility of using CZT-SPECT/CT imaging as an alternative approach by assessing the absolute quantification of myocardial tracer uptake, expressed as standardized uptake values (SUV), both at rest and during stress. The primary objective is to compare the ratio of stress-

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Participant has provided informed consent to participate in the study. 2. Age ≥ 18 years. 3. Patients referred for functional cardiac imaging assessment (SPECT or PET) following diagnostic coronary CT angiography (CCTA) or invasive coronary angiography demonstrating either: * moderate coronary atherosclerosis without significant coronary stenosis (\<50% stenosis), or * coronary lesions for which functional cardiac imaging assessment or medical therapy is indicated. Exclusion Criteria: 1. Severe coronary artery disease requiring prompt revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), including left main coronary artery stenosis \>50% or other severe coronary lesions with FFR \<0.80. 2. History of coronary revascularization (PCI, coronary stenting, or CABG). 3. Left ventricular ejection fraction (LVEF) \<35%. 4. Contraindication to pharmacological stress testing for cardiac PET/SPECT, including severe hypotension, second- or third-degree atrioventricular block, or recent myocardial infarction. 5. Protected adult under legal guardianship or curatorship. 6. Individual under judicial protection measures. 7. Individual deprived of liberty. 8. Individual not affiliated with a health insurance 9. Pregnant or breastfeeding woman.
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What it tests

  • stress SPECT/CT
  • rest SPECT/CT
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Where

1 site
Centre Hospitalier Universitaire d'Orléans
Orléans, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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