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โ† Trials
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MRI Performance and Risk Factors in Bilateral Vestibular Hypofunction

Recruitingn/aAges 16 Years - anyAllShanghai 6th People's Hospital
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In plain words

What the trial is, and whether it could suit you

Bilateral vestibular hypofunction (BVH) is a chronic disorder in which the balance organs or vestibular pathways on both sides do not work normally. People with BVH may experience unsteadiness, blurred or unstable vision during head movement, difficulty walking, and an increased risk of falls. At present, there are limited targeted medical treatments, and the reasons why symptoms are severe in some patients but mild in others are not fully understood. This prospective, multicenter, cross-sectional study will investigate the relationships among vestibular function, brain structure and function, blood biomarkers, patient-reported symptoms, and disease severity in people with BVH. The study will enroll approximately 120 participants from five medical centers in China, including about 80 patients with BVH and 40 age-matched healthy controls. Participants will undergo vestibular function te

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Sex unrestricted, age over 16 years old. 2. Patients meeting the diagnostic criteria for bilateral vestibulopathy (BVP) and presbyvestibulopathy (PVP) 3. Participants or their legal representatives, who comprehensively understand the research purpose, demonstrate sufficient compliance with the study protocol, have the ability to communicate and cooperate, and have signed the informed consent form. Exclusion Criteria: 1. Administration of medications potentially affecting cerebral function, including psychotropic drugs (antidepressants, anxiolytics) or prolonged anti-vertigo medication usage. 2. Presence of severe cardiovascular or systemic medical conditions, organ dysfunction, or significant mobility impairments. 3. Significant local or systemic diseases, or psychiatric disorders causing cognitive impairment, specifically schizophrenia, major depressive disorder, or generalized anxiety disorder. 4. Pregnant or lactating women. 5. Participation in alternative pharmaceutical or medical device clinical trials within the preceding 3-month period. 6. Clinically significant head movement restrictions. 7. Subjects assessed by investigators as unsuitable for study participation. 8. Individuals with contraindications for MRI, including cardiac pacemakers, implanted electronic devices, claustrophobia, metallic implants incompatible with magnetic resonance imaging and medications potentially compromising MRI scan safety.
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What it tests

  • Multimodal Neuroimaging and Vestibular Function Assessment
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Where

1 site
shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Shanghai, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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