Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients

Inclusion Criteria: * Mechanically ventilated adult patients ≥ 21 years. * Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status. * Hemodynamically stable \[mean arterial pressure (MAP) ≥60 mmHg\]. * All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive. Exclusion Criteria: * Patients with neuromuscular disorders affecting respiratory drive * Glasgow Coma Scale (GCS) score below 8 * Cervical spinal cord injury * Receipt of neuromuscular blockers within the previous 24 hours * Morbid obesity resulting in unreliable respiratory mechanics * Pregnancy * Deep sedation defined as RASS ≤ -2 * Hemodynamic instability requiring escalating vasopressor support.