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Pumpkin Seed Oil as a Nutraceutical for Hemodialysis Patients

RecruitingNAAges 18 Years - anyAllAl-Mustansiriyah University
NCT07710183 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with end-stage renal disease (ESRD) on maintenance hemodialysis experience chronic systemic inflammation, oxidative stress, and dyslipidemia, which together drive much of the excess cardiovascular morbidity and mortality seen in this population. Pumpkin seed oil is a nutraceutical rich in polyunsaturated fatty acids, phytosterols,and tocopherols, with documented antioxidant, anti-inflammatory, and antihyperlipidemic properties in preclinical and limited clinical studies. This study investigates the potential role of pumpkin seed oil as a nutraceutical on the clinical and biochemical outcomes of hemodialysis patients. It is a randomized, open-label, prospective interventional study in which daily oral supplementation with pumpkin seed oil (1000 mg once daily) for 3 months is evaluated against usual care. Eighty-five participants will be assigned to either an intervention group (n

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📋 Eligibility rules (as published)
Inclusion Criteria: * End-stage renal disease (ESRD) on hemodialysis for more than 6 months, on a constant dialysis program. * Hemodynamically stable (no recent hospitalization for infections, cardiovascular events, or major surgery within the past 3 months). * No active acute infections. * Serum albumin ≥ 3.0 g/dL. Exclusion Criteria: * Regular intake of dietary supplements (e.g., omega-3, antioxidants) for at least one month prior to enrollment. * Autoimmune disease, liver disease, cancer, or acquired immunodeficiency syndrome (AIDS). * Known sensitivity/allergy to pumpkin seed oil. * Current use of lipid-lowering agents. * Diabetes mellitus. * Current use of anticoagulants (warfarin, direct oral anticoagulants). * Current use of immunosuppressants, corticosteroids, or anti-inflammatory drugs. * Pregnant or breastfeeding women. * Residual kidney function (urine output \> 200 mL/day).
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What it tests

  • Pumpkin Seed Oil 1000 mg
  • Standard hemodialysis care
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Where

1 site
Al-Karama Teaching Hospital, Hemodialysis Center
Baghdad, Iraq
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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