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Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I)

RecruitingNAAges 21 Years - 70 YearsAllNational University Health System, Singapore
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In plain words

What the trial is, and whether it could suit you

The primary objective of the Personalized Responses \& Integrated Systems for Metabolism (PRISM-I) pilot study is to assess the feasibility of conducting a definitive randomized controlled trial evaluating precision lifestyle interventions for improving insulin resistance in adults with metabolic syndrome.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Participants will be included for if they are: * (1) adults aged 21-70 years old; * (2) willing and able to comply with using a CGM, smart ring, food logging app * (3) able to provide written informed consent; * (4) English-speaking and literate; * (5) meet the inclusion criteria for metabolic syndrome and insulin resistance. * The criteria for insulin resistance is HOMA-IR โ‰ฅ 2.5. * The criteria for metabolic syndrome is to have high waist circumference (โ‰ฅ 80cm for females and โ‰ฅ 90cm for males); and any two of the four below: * (1) raised triglycerides: 1.7 mmol/L or on treatment; * (2) reduced HDL cholesterol: \< 1.0 mmol/L (40 mg/dL) in men, \< 1.3 mmol/L (50 mg/dL) in women, or on treatment; * (3) high blood pressure: 130/85 mmHg or on treatment; or * (4) raised fasting glucose: 5.6 mmol/L (100 mg/dL) or previously diagnosed with T2DM Exclusion Criteria: Participants will be excluded from both phases if they are: * (1) on insulin therapy; * (2) are pregnant or lactating; * (3) have a medical condition or are on a treatment that may interfere with study participation or metabolic assessments, as determined by the study investigators; * (4) currently participating in other lifestyle modification programs.
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What it tests

  • Time-restricted eating
  • Physical Activity
  • Low Glycemic Load diet
  • Sleep hygiene
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Where

1 site
National University of Singapore
Singapore, Singapore
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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