Phase II Study of Becotatug Vedotin Plus Pucotenlimab for Advanced Refractory Solid Tumors With EGFR-Positive

Inclusion Criteria: 1. Age≥18 years at the time of signing the informed consent form (ICF). 2. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 7 days prior to the first dose. ECOG 2 is allowable if it is solely attributable to tumor progression, as judged by the investigator. 3. Life expectancy≥ 12 weeks. 4. Histologically or cytologically confirmed locally advanced or metastatic solid tumors that have failed standard therapy (progressive disease or intolerance to prior treatment), or for whom standard therapy is currently not applicable or unavailable. There is no limit on the number of prior lines of therapy. 5. Documentation of EGFR expression status is required for enrollment. If not available, the subject must provide adequate fresh or archival tumor tissue samples for EGFR testing. If adequate tumor specimens cannot be provided, a repeat biopsy may be performed if deemed feasible and safe by the investigator and after obtaining the subject's consent; however, repeat biopsy is not mandatory. In cases where repeat biopsy is not feasible or the subject refuses, eligibility must be jointly confirmed by the investigator and the sponsor. 6. EGFR expression positive (2+ or 3+) as determined by immunohistochemistry (IHC). 7. At least one measurable lesion per RECIST version 1.1. 8. Adequate organ function, as defined by the following criteria (no blood components, cell growth factors, leukopoiesis agents, thrombopoiesis agents, or anemia-correcting drugs are allowed within 14 days prior to the first dose): A. White blood cell count (WBC) ≥ 3.0 x 10\^9/L; absolute neutrophil count (ANC) ≥ 2.0 x 10\^9/L. B. Hemoglobin (HB) ≥90 g/L. C. Platelet count ≥ 100x10\^9/L. D. Serum albumin ≥ 2.8 g/dL. E. Total bilirubin ≤1.5 x upper limit of normal (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3.0 x ULN. F. Serum creatinine ≤ 1.5 x ULN or creatinine clearance \> 60 mL/min. G. Activated partial thromboplastin time (APTT) and international normalized ratio (INR) ≤ 1.5 x ULN (subjects receiving stable doses of anticoagulants, such as low-molecular-weight heparin or warfarin, with INR within the expected therapeutic range for the anticoagulant, are eligible for screening). 9. No contraindications to chemotherapy, targeted therapy, or immunotherapy. 10. No history of immune-related diseases. 11. No uncontrolled pneumonia or pulmonary infection. 12. Females of childbearing potential must agree to use effective contraception during the trial; a serum or urine pregnancy test must be negative within 72 hours before the start of chemotherapy. 13. Subjects must be compliant, able to undergo treatment and follow-up, and willing to comply with the study requirements as specified in the protocol. 14. For male subjects with partners of childbearing potential, effective medical contraception must be used from the signing of the ICF until 6 months after the last dose. 15. Subjects must voluntarily sign the ICF and be able to comply with the protocol-specified visits and procedures. Exclusion Criteria: 1. Presence of uncontrolled serious medical conditions, including severe cardiac disease, cerebrovascular disease, uncontrolled diabetes, uncontrolled hypertension, uncontrolled infection, active peptic ulcer, etc. 2. History of allergy or hypersensitivity to any component of monoclonal antibody-based agents, or known allergic constitution. 3. Uncontrolled cardiac symptoms or diseases, such as: * New York Heart Association (NYHA) Class ≥ II heart failure, or left ventricular ejection fraction (LVEF) \< 50% on echocardiography; * Unstable angina; * Myocardial infarction within 1 year; * Clinically significant supraventricular or ventricular arrhythmias requiring intervention (including QTc interval≥470 ms). 4. Severe infection (CTC AE \> Grade 2) within 4 weeks before the first dose, such as severe pneumonia requiring hospitalization, bacteremia, infectious complications, etc.; evidence of active pulmonary inflammation on baseline chest imaging; signs or symptoms of infection or need for oral or intravenous antibiotics (excluding prophylactic antibiotics) within 2 weeks before the first dose. 5. Unexplained fever \> 38.5 ℃ during screening or before the first dose (subjects with tumor fever, as judged by the investigator, may be enrolled). 6. Active autoimmune disease or history of autoimmune disease (e.g., interstitial pneumonia, colitis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism, including but not limited to these). Exceptions include: autoimmune-mediated hypothyroidism treated with stable doses of thyroid-replacement hormones; type 1 diabetes mellitus controlled with stable insulin; vitiligo; or childhood asthma/allergy that has resolved and requires no intervention in adulthood. 7. History of immunodeficiency, including HIV-positive status, other acquired or congenital immunodeficiency diseases, or history of organ transplantation or allogeneic bone marrow transplantation. 8. Untreated chronic hepatitis B, or hepatitis B virus (HBV) DNA \> 500 IU/mL, or active hepatitis C virus (HCV) infection. Subjects with inactive hepatitis B surface antigen (HBsAg) carriers, treated and stabilized hepatitis B (HBV DNA \< 500 IU/mL), or cured hepatitis C may be enrolled. 9. History of interstitial lung disease (excluding radiation pneumonitis that has not been treated with corticosteroids) or non-infectious pneumonitis. 10. Active pulmonary tuberculosis infection by history or CT findings, or history of active tuberculosis within 1 year before enrollment, or history of active tuberculosis more than 1 year ago without adequate treatment. 11. Prior receipt of any of the following treatments: A. Any investigational drug within 4 weeks before the first dose. B. Last dose of anticancer therapy (including chemotherapy, radiotherapy, targeted therapy, etc.) ≤ 4 weeks before the first dose. C. Systemic cort