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β2M Post-HD Rebound Prediction

Recruitingn/aAges 18 Years - anyAllEast and North Hertfordshire NHS Trust
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In plain words

What the trial is, and whether it could suit you

β2-Microglobulin is small 11.8 kDa protein presents on the surface of all nucleated cell in the human body, it forms part of the non-variable chain of Major Histocompatibility Complex class I. β2-Microglobulin production is constant and it is continuously released into the bloodstream. Its production increases during active infections, inflammation or blood cancers. The Kidneys are the main route of its elimination. It accumulates in patients with kidney disease and levels can rise significantly in patients with end-stage renal failure. Studies have shown that its accumulation in dialysis patients contributes to dialysis-related amyloidosis. Haemodialysis is a significant contributor to removal of β2-microglobulin in those on dialysis. It removes β2-microglobulin from the blood rather than directly from tissues. Blood levels fall during dialysis. However, after haemodialysis, β2-microgl

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or above. * Ability to give informed consent. * End Stage Renal Disease established on maintenance haemodialysis for at least 3 months Exclusion Criteria: * Inability to give informed consent. * Acute infection in last 2 weeks.
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What it tests

  • β2-microglobulin blood concentration in mg/L
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Where

1 site
East and North Hertfordshire NHS Trust
Stevenage, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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