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TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllTreeline Biosciences, Inc.
NCT07713732 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this first-in-human study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of TLN-499 in combination with venetoclax in participants with relapsed/refractory solid tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adults ≥18 years of age 2. Histologically confirmed relapsed/refractory SCLC, neuroendocrine cancer, malignant pleural mesothelioma, or synovial sarcoma 3. Measurable disease per RECIST v1.1 or mRECIST 4. ECOG performance status 0-1 5. Adequate hematologic, hepatic, renal, and coagulation function. 6. Life expectancy ≥12 weeks 7. Signed informed consent Exclusion Criteria: 1. Active brain metastases 2. Major surgery or severe trauma within 4 weeks before first dose 3. Significant uncontrolled medical conditions preventing study participation 4. Use of prohibited concomitant medications 5. Previous conditions that would interfere with study assessments or safety
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What it tests

  • TLN-499
  • Venetoclax
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Where

3 sites
COBL Clinical Trials - Chris O'Brien Lifehouse
Camperdown, Australia
Cabrini Hospital Malvern
Malvern, Australia
Linear Clinical Research
Nedlands, Australia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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