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Hyaluronic Acid Versus Platelet-Rich Plasma for Chronic Tendinopathy and Enthesopathy

RecruitingNAAges 18 Years - 65 YearsAllOrtonika Orthopedic Medical Clinic in Lublin
NCT07714811 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic tendinopathies and enthesopathies are common musculoskeletal conditions in orthopedics and sports medicine, frequently leading to pain, impaired function, and significantly reduced quality of life. Their pathogenesis involves tissue degeneration and ineffective repair response, often without an active inflammatory process. Standard conservative management based on physiotherapy and activity modification is often prolonged and not always satisfactory. Minimally invasive injectable interventions supporting tendon and enthesis regeneration represent a promising alternative due to their favorable safety profile and outpatient feasibility. Hyaluronic acid (HA) is a glycosaminoglycan naturally present in connective tissues. In the context of tendinopathy, it is thought to modulate inflammatory processes, provide mechanical protection by reducing friction and adhesion within the tendo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Chronic tendinopathy or enthesopathy of the Achilles tendon or tendon insertion in the elbow region (medial epicondylopathy, so-called golfer's elbow) * Symptom duration exceeding 3 months * Pain intensity of at least 40 millimeters (mm) on a 100-mm Visual Analog Scale (VAS) * Age 18-65 years * Signed written informed consent Exclusion Criteria: * Previous surgical treatment of the studied tendon or tendon insertion * Prior injection of corticosteroids, platelet-rich plasma (PRP), or hyaluronic acid into the area being studied within 3 months before enrollment * Active systemic or local infection at the planned injection site * Systemic inflammatory or autoimmune disease involving the joints, including rheumatoid arthritis, spondyloarthritis, or systemic lupus erythematosus * Pregnancy or breastfeeding * Body mass index (BMI) of 40 kilograms per square meter (kg/m²) or greater
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What it tests

  • Hyaluronic acid injection
  • Autologous Platelet-Rich Plasma Injection
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Where

1 site
Ortonika Orthopedic Medical Clinic in Lublin
Lublin, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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