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Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia

RecruitingEARLY Phase 1Ages 18 Years - 45 YearsFemaleAnna Stanhewicz, PhD
NCT07715669 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life. They are also more likely to have depression after pregnancy. Why they are more likely to develop these conditions is not known. It may be because their blood vessels were damaged during pregnancy. Changes in blood vessel health can predict heart disease. These changes have been recorded after pregnancy in women who had preeclampsia. These changes have also been recorded in women who have depression. In the previous phase of this award, we found that women who had preeclampsia in pregnancy had changes in blood vessel health after pregnancy. We also found that if these women were taking a medicine to treat depression, their blood vessel health was normal. This could mean that treatment for d

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18-24 years old, * 12 weeks - 5 years post pregnancy * one of the following: * history of a normal pregnancy with a current diagnosis of depression, * history of a normal pregnancy without a current diagnosis of depression, * history of a preeclamptic pregnancy with a current diagnosis of depression * history of preeclamptic pregnancy without a current diagnosis of depression. Exclusion Criteria: * history of cardiovascular, metabolic, and/or skin diseases * current or history of tobacco/nicotine/ e-cigarette use * history of gestational diabetes * current antihypertensive or cholesterol-lowering medication * currently pregnant * allergy to materials used during the experiment (e.g. latex), * known allergy to study drugs * currently using SSRI medications
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What it tests

  • Paroxetine Hydrochloride
  • Ascorbic acid (Vitamin C)
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Where

1 site
University of Iowa
Iowa City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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