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Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock Patients

RecruitingNAAges 18 Years - anyAllAlexandria University
NCT07716956 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to assess the effect of targeting upper normal serum magnesium levels on norepinephrine requirements in adult patients with septic shock. The main questions it aims to answer are: 1. Does maintaining upper normal serum magnesium levels lower the total cumulative dose and duration of norepinephrine therapy? 2. Does this approach reduce the intensive care unit (ICU) length of stay, duration of mechanical ventilation and mortality? This study will compare an intervention group to a control group to see the effect of targeting upper normal serum magnesium levels. Participants will: * Have their serum magnesium levels assessed at baseline (Day 0), at three-day intervals (Days 3, 6, 9) thereafter and on the day of norepinephrine discontinuation. * Receive individualized intravenous magnesium sulfate infusions to achieve and maintain the target serum magn

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female adult patients (aged ≥18 years) diagnosed with septic shock. * Resistant septic shock that requires corticosteroids. Exclusion Criteria: * Pregnancy. * Baseline hypermagnesemia (serum magnesium level \> 2.3 mg/dL). * Renal impairment with creatinine clearance (CrCl) \< 10 ml/min. * Mixed shock.
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What it tests

  • magnesium sulfate
  • standard care treatment
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Where

1 site
Alexandria Main University Hospital
Alexandria, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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