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Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery

Recruitingn/aAges 18 Years - anyAllARNAS Civico Di Cristina Benfratelli Hospital
NCT07717827 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Brain tumor surgery in so-called "eloquent" brain areas aims to remove as much tumor as possible while preserving neurological functions. Standard surgical planning typically focuses on discrete, anatomically defined cortical regions. However, modern neuroscience demonstrates that most brain functions arise from distributed networks of interconnected areas rather than isolated spots - a concept that standard navigation tools do not fully capture. The CORTEX study evaluates a surgical workflow - termed "connectome-guided network-based navigation" - in which advanced diffusion MRI processing is used to reconstruct patient-specific maps of white matter pathways and large-scale brain networks. These maps are imported into a clinical neuronavigation system to guide preoperative planning and intraoperative decision-making for patients with gliomas or brain metastases in eloquent regions. The

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📋 Eligibility rules (as published)
Inclusion Criteria: * Indication for supratentorial brain tumor surgery (glioma or metastasis) * Lesion located within or adjacent to eloquent cortical or subcortical regions (motor, language, visual, or higher-order associative networks, as defined by clinical and neuroimaging criteria) * Availability of standardized preoperative and early postoperative brain MRI (including high-direction diffusion tensor imaging, ≥64 directions) * Consistent postoperative clinical follow-up planned at the treating centre * Provision of informed consent for use of anonymized clinical and imaging data Exclusion Criteria: * Inability to undergo pre- or postoperative MRI * Significant comorbidities precluding surgery * Incomplete imaging or clinical data * Purely infratentorial lesions or non-tumoral pathologies
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What it tests

  • Connectome-guided network-based neuronavigation
  • Advanced diffusion MRI tractography and connectome pipeline
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Where

1 site
Unit of Neurosurgery - A.R.N.A.S. Civico Di Cristina Benfratelli - 90127, Palermo - Italy
Palermo, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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