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5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery

RecruitingNAAges 21 Years - 65 YearsAllCairo University
NCT07719075 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment. Because it can lead to serious organ injury, prompt prevention and management are essential. Vasopressors, including ephedrine, phenylephrine, and norepinephrine, are commonly used, with NE gaining interest as an intraoperative bolus despite uncertainty about the optimal dose in general surgery population The aim of this study is to compare 5 mcg to 10 mcg norepinephrine bolus for treatment of postinduction hypotension and early intraoperative in emergency abdominal surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients, American Society of anesthesiologists (ASA) I-III undergoing emergency abdominal surgery Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) * Patients on vasopressor infusion, * Pregnant or lactating women, * Allergy of any of the study drugs
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What it tests

  • Norepinephrine 10 mcg
  • Norepinephrine 5 mcg
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Where

1 site
Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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