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Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)

RecruitingNAAges 18 Years - anyAllStephan Baldus
NCT07721649 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS) or congestive heart failure (CHF), compared with active counseling alone, on influenza vaccination rates in patients at high cardiovascular risk. Patients are randomized 1:1 to either an offer of bedside intrahospital influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO) in addition to standardized active counseling (intervention group), or standardized active counseling plus the standard-of-care recommendation for ambulatory vaccination in the discharge papers (control group). The primary endpoint is the influenza vaccination rate at the end of the index season (March 31).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Hospitalized due to acute coronary syndrome (ACS) or congestive heart failure (CHF) and fulfilling the criteria for influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO) * Written informed consent Exclusion Criteria: * Already received seasonal influenza vaccination in the current season, based on self-reported vaccination status and/or vaccination certificate * Laboratory-confirmed active influenza infection during the index hospitalization * Contraindication for vaccination (e.g., known allergy) * Inability to provide written informed consent
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What it tests

  • Intrahospital seasonal influenza vaccination offer
  • Standardized active influenza vaccination counseling
  • Standard of care discharge recommendation for ambulatory vaccination
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Where

2 sites
Clinic III for Internal Medicine, University Hospital of Cologne
Cologne, Germany
Department of Cardiology, University Heart and Vascular Centre Hamburg
Hamburg, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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