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The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation

RecruitingNAAges 18 Years - anyAllLondon Health Sciences Centre Research Institute …
NCT07726134 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Delayed graft function, defined as the need for dialysis within seven days of kidney transplantation, is a common complication affecting deceased-donor kidney transplant recipients. It is associated with prolonged hospitalization, increased healthcare costs, higher rates of acute rejection, and poorer long-term graft survival. Intraoperative diuretics are routinely administered during kidney transplant surgery to promote early urine output and protect the kidney from injury during reperfusion. The two most commonly used agents are furosemide and mannitol. Despite decades of clinical use, no prospective randomized trial has directly compared these two medications, and practice remains highly variable across centres and individual surgeons. This single-centre, prospective, randomized, surgeon-blinded pilot trial will enroll 240 deceased-donor kidney transplant recipients at London Health S

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age \>18 years; 2. Patient is scheduled to receive a deceased-donor kidney transplant (including both NDD and DCD donors) 3. Patient is willing and able to provide written and informed consent, or a substitute decision maker (SDM) is available to sign on the patient's behalf Exclusion Criteria: 1. Patient is receiving another organ at the time of their kidney transplant (e.g., simultaneous kidney-pancreas or kidney-liver) 2. Known allergy or contraindication to mannitol or furosemide 3. Inability to provide informed consent 4. Pediatric recipients (\<18 years of age) 5. Previously enrolled in this clinical trial
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What it tests

  • Furosemide
  • Mannitol
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Where

2 sites
London Health Sciences Centre
London, Canada
University Hospital - London Health Sciences Centre
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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