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โ† Trials
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Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1

RecruitingNAAges 12 Years - 60 YearsAllXijing Hospital
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In plain words

What the trial is, and whether it could suit you

Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy. Temporal interference (TI) stimulation is a recently developed noninvasive neuromodulation technique that enables focal modulation of deep brain structures. In this randomized, double-blind study, we developed a theta-burst patterned TI protocol and evaluated its effects in patients with NT1.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Aged 12 to 60 years. * Diagnosis of narcolepsy type 1 according to the International Classification of Sleep Disorders, Third Edition (ICSD-3), confirmed by polysomnography (PSG) and/or Multiple Sleep Latency Test (MSLT) performed within the past 10 years, with the test procedures meeting the minimum technical standards specified in the ICSD-3. * Epworth Sleepiness Scale score \>12 at baseline. * Signed informed consent. Exclusion Criteria: * Presence of other conditions that cause excessive daytime sleepiness, including restless legs syndrome, periodic limb movement disorder, or moderate-to-severe obstructive sleep apnea syndrome, etc. * History of epilepsy, severe neuropsychiatric disorders, or significant cardiac, hepatic, or renal dysfunction. * Pregnancy or current breastfeeding. * Contraindications to MRI or electrical stimulation therapy, such as intracranial metallic foreign bodies, cardiac pacemakers, implantable cardioverter-defibrillators, or cochlear implants.
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What it tests

  • Active Temporal Interference Stimulation
  • Sham Temporal Interference Stimulation
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Where

1 site
Xijing Hospital
Xi'an, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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