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Preoperative Genicular Radiofrequency and Functional Outcomes After Total Knee Arthroplasty

RecruitingNAAges 18 Years - 60 YearsAllAnesthesiology department Iris South Hospitals
NCT07727551 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Knee osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage wear, leading to pain, stiffness, and joint swelling. It is highly prevalent in aging populations and is strongly associated with obesity and previous joint injury. OA affects millions of individuals worldwide, with incidence and prevalence increasing markedly with age and resulting in significant functional disability The primary therapeutic goals in the management of knee osteoarthritis are pain reduction and improvement of joint mobility. Total knee arthroplasty is considered one of the most effective surgical interventions for relieving pain and restoring function in patients with severe knee osteoarthritis. Nevertheless, residual pain and limited functional improvement remain the most frequent causes of patient dissatisfaction following TKA Genicular nerve radiofrequency ablation (GNRF

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 60 * Elective total knee arthroplasty * 2 to 6 weeks before the procedure AND either of: * BMI \> 35 * Diabetes under insulin * Anxiety disorder * Treated depressive disorder * Widespread pain disorder or central sensitisation disorder * Chronic pain at a different site * Catastrophising * Sleep disorder * preoperative EVA 7 or more * OKS 25 or less * WOMAC 50 or more * Previous total knee arthroplasty (contralateral) * Knee CRPS Exclusion Criteria: * Previous prosthetic surgery on the same knee (i.e. redo surgery, open reduction internal fixation, knee hemiarthroplasty) * Major psychiatric disorder (i.e. major depression, schizophrenia) * Patient refusal * Inability to communicate with the patient and obtain informed consent
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What it tests

  • Radiofrequency ablation of the genicular nerve, 42 degrees Celsius for 120 seconds
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Where

1 site
Iris South Hospitals
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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