Perioperative Statins to Prevent AFib After Lung Surgery

Inclusion Criteria: * Age 60 years or older. * Scheduled to undergo isolated anatomical lung resection, including pulmonary segmentectomy or lobectomy. * Sinus rhythm documented by a preoperative electrocardiogram. * Not receiving antiarrhythmic medication, with the exception of beta-blockers. * Willing and able to provide written informed consent. Exclusion Criteria: * Untreated hyperthyroidism or hypothyroidism. * History of obstructive hepatobiliary disease, active liver disease, or other serious liver disease. * Preoperative serum creatinine greater than 150 μmol/L. * Known allergy to atorvastatin or another statin, or a history of a serious statin-related adverse reaction, including statin-associated myopathy. * Personal or family history of an inherited muscle disorder. * Continuous use within 1 month before randomization of fibrates, niacin, or medications that strongly inhibit cytochrome P450 or P-glycoprotein, including cyclosporine, oral azole antifungal agents, certain interacting antibiotics, protease inhibitors, nefazodone, or amiodarone. * Consumption of 1 liter or more of grapefruit juice per day within 1 month before randomization. * Current treatment with a high-intensity statin regimen, including atorvastatin 40 mg/day or higher or rosuvastatin 20 mg/day or higher. * Any other condition that, in the investigator's judgment, would make participation unsafe or interfere with the conduct or evaluation of the study.