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CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure

Recruitingn/aAges 18 Years - anyAllMinia University
NCT07727759 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the future liver remnant (FLR) - cannot meet the body's metabolic needs. PHLF occurs after roughly 5% to 15% of major hepatectomies and is the leading cause of postoperative death. Before surgery, surgeons routinely use CT scans to measure how much liver will remain (CT volumetry). Volume alone does not tell the whole story. After a large resection the remaining liver can rotate and shift into the empty space left behind, kinking or compressing the veins that drain it. The resulting congestion can make an apparently adequate remnant fail. This prospective, multicenter, observational cohort study tests whether adding two elements to standard CT volumetry improves the

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Scheduled to undergo major hepatic resection, defined as the removal of three or more Couinaud segments, at a participating center * Availability of a preoperative multiphasic contrast-enhanced CT of the liver of quality sufficient for central core-laboratory analysis * Willing and able to complete postoperative clinical and laboratory follow-up for at least 30 days * Written informed consent Exclusion Criteria: * Minor hepatic resection (fewer than three Couinaud segments) * Significant pre-existing vascular anomaly or vascular pathology (for example, portal vein thrombosis) * Emergency hepatic resection for trauma * Preoperative imaging that fails central quality control * Incomplete follow-up data
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What it tests

  • Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
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Where

3 sites
Liver and GIT Hospital, Faculty of Medicine, Minia University
Minya, Egypt
Maadi Armed Forces Medical Compound - Department of Liver and Pancreas Surgery and Liver Transplantation
Maadi, Egypt
National Liver Institute, Menoufia University
Shibฤซn al Kawm, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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