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A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age

RecruitingPhase 4Ages 18 Years - 64 YearsAllBioNTech SE
NCT07730450 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to learn about the safety and effects of an updated COVID-19 vaccine (called BNT162b2) in adults 18 to 64 years of age. This study is seeking participants who: * are medically stable * have not had a recent COVID-19 infection * have not had a recent vaccination * do not have medical conditions that increase their risk of complications from COVID-19 All participants in this study will randomly receive 1 injection into their arm of either: * BNT162b2 vaccine which targets COVID-19 and is selected for the 2026-2027 COVID-19 season, or * Tdap vaccine which targets tetanus, diphtheria, and pertussis (whooping cough). The study team and participants will not know which injection they receive. We will evaluate safety and SARS-CoV-2 spike protein levels in people receiving each of these vaccines. Participants will be in the study for about 12 months.

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📋 Eligibility rules (as published)
Key Inclusion Criteria \- Healthy participants 18 through 64 years of age who do not have medical conditions that put them at a higher risk for severe COVID-19. Key Exclusion Criteria * Participants who tested positive for COVID-19 within 6 months (180 days) prior to Visit 1 * Participants who have recently received a vaccine, or plan to receive a nonstudy COVID-19 or comparator vaccine during participation. The complete list of inclusion and exclusion criteria are listed in the protocol.
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What it tests

  • BNT162b2 Vaccine
  • Tdap Vaccine
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Where

5 sites
Diablo Clinical Research, LLC dba Flourish Research
Walnut Creek, United States
Palm Springs Community Health Center
Miami Lakes, United States
East-West Medical Research Institute
Honolulu, United States
Duke Vaccine and Trials Unit
Durham, United States
J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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