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Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses

RecruitingNAAges 18 Years - anyAllPatrick Morris
NCT07731555 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective study aims to characterize blood brain barrier (BBB) disruption in patients with newly diagnosed glioblastoma multiforme undergoing surgical resection. The study integrates advanced MRI, circulating BBB biomarkers, neurocognitive assessment, and molecular analysis of tumor tissue to investigate relationships between BBB integrity, tumor biology, and neurological function. Participants will undergo serial assessments before surgery, after surgery, and following radiotherapy. Tumor tissue collected during standard-of-care resection will undergo immunohistochemical and transcriptional

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients aged 18 years or older. * Newly diagnosed glioblastoma. * Selected for surgical tumor resection. * Able and willing to provide written informed consent. * Able to undergo study assessments and follow-up procedures. Exclusion Criteria: * Contraindication to magnetic resonance imaging. * Confusion, delirium, or altered state of consciousness that interferes with the ability to provide informed consent. * Any condition that, in the opinion of the investigator, would prevent completion of study procedures or compromise participant safety.
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What it tests

  • Multimodal Blood Brain Barrier Assessment
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Where

1 site
Beaumont RCSI Cancer Centre
Beaumont, Ireland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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