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Study of Repetitive Behaviors in Alzheimer's Disease

Recruitingn/aAges 18 Years - anyAllCentre Hospitalier Esquirol
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In plain words

What the trial is, and whether it could suit you

Alzheimer's disease (AD) is characterized by anterograde amnesia, the inability to memorize and remember events occurring after the cerebral lesion. Among the most frequently reported psychobehavioral symptoms are repetitive behaviors (RBs), defined as actions or statements repeated in an inappropriate and non-functional way. The most commonly used tool to assess repetitive behaviors is the Stereotypy Rating Inventory (SRI). It is a questionnaire that evaluates five types of stereotypical behavior: eating, wandering, speech, movements, and daily routines. The frequency and severity of the behaviors are reported, and a total score can be calculated. There is no consensus on the types of repetitive behaviors observed specifically in AD, their frequency, or their cognitive correlates, nor is there a hypothesis explaining why these symptoms do not occur in all AD patients. Furthermore, cer

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: I- RB+ (n=42) and RB- (n=30) groups : 1. MMSE \> 20 2. 1 reliable family caregiver identified per patient 3. Patients under legal protection (guardianship/curatorship) or not 4. Selection: 4.a. AD patients with an SRI score \> 0 will constitute the RB+ subgroup. 4.b. Only the first 30 patients included will undergo V2, V3, and V4. The first 30 AD patients included with an SRI score = 0 will constitute the RB- subgroup. II- Control group: healthy subjects (n=30) 1. Healthy subjects 2. MMSE โ‰ฅ 26/30 3. Men and women matched to AD patients in terms of age and sociocultural level. 4. Healthy subjects will be included by the CMRR in Limoges III- Control group: Patient with anterograde amnesia (AA) (n=1): 1. The patient with anterograde amnesia is a patient who participated in the ANISAAFORNIX study (another study submitted by the investigator) and is included in this study due to rich RB symptomatology. He is a 54-year-old man with lesions of the fornix following complications from neurosurgery, which led to severe anterograde amnesia. This patient does not have AD. 2. This patient is under legal protection (guardianship). 3. Patient monitored and included at the CMRR in Limoges. Exclusion Criteria: I- RB+ and RB- groups and healthy subjects: 1. Isolated participants (without an identified caregiver) (RB+ and RB- groups) 2. Participants must not have a history of alcohol or other substance dependence in the past 12 months. 3. Participants must not have any other neurological condition (with the exception of patients with AA anterograde amnesia). Any history of moderate to severe head trauma, stroke, or developmental disorders is a criterion for exclusion.
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What it tests

  • Not listed
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Where

1 site
Esquirol Hospital Center
Limoges, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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