๐ฌIn plain words
What the trial is, and whether it could suit you
The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritis
Sign in to get the eligibility rules as simple questions to take to your doctor.
๐ Eligibility rules (as published)
Inclusion Criteria:
* Age group 40-70
* Both genders male and female
* Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee.
* Pain stable enough to permit exercise on Numeric Pain Rating Scale 3/10.
* Participants must demonstrate a gastrocnemius muscle strength of grade โฅ3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position.
* Participants must be able to ambulate independently and participate in supervised exercise.
Exclusion Criteria:
* โข Presence of a prosthetic knee in the affected limb.
* Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA.
* Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension โฅ160/100 mmHg).
* Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation).
* History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding/clotting disorders.
* Current anticoagulant therapy that increases bleeding risk (unless cleared by physician).
* Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).
๐
What it tests
- Eccentric Gastrocnemius Strengthening Exercises
- Low-Load Blood Flow Restriction Training
Railway General Hospital, Rawalpindi
Rawalpindi, Pakistan
๐ค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ always decide together with your own doctor.