Physical Activity Promotion and Clinical Remission in Severe Asthma

Inclusion Criteria: * Adults aged 18-70 years. * Physician-diagnosed severe asthma. * Eligible for tezepelumab according to NICE TA880. * History of ≥3 asthma exacerbations requiring oral corticosteroids in the previous 12 months or receiving maintenance oral corticosteroid therapy. * Objective confirmation of asthma, including bronchodilator reversibility, bronchial hyperresponsiveness and/or variable airflow obstruction, as part of routine clinical assessment. * Decision to commence tezepelumab made by the treating multidisciplinary severe asthma team prior to study enrolment. * Able and willing to provide written informed consent. Exclusion Criteria: * Non-asthma respiratory disease that may confound study outcomes (e.g. obstructive sleep apnoea). * Pregnancy. * Significant non-asthma medical conditions likely to impair physical activity or functional exercise capacity (e.g. acute musculoskeletal injury). * Any condition that, in the opinion of the investigator, would make participation unsafe or compromise study completion.