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Comparison of Postoperative Analgesic Efficacy of Two Different Blocks in Modified Radical Mastectomy Surgery

RecruitingNAAges 18 Years - 65 YearsFemaleSultan Abdulhamid Han Training and Research Hospi…
NCT07737132 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Postoperative pain following modified radical mastectomy remains a significant clinical challenge and may delay recovery, impair patient comfort, and increase opioid consumption. Ultrasound-guided fascial plane blocks have become an important component of multimodal analgesia for breast surgery. The serratus anterior plane block (SAPB) is an established regional anesthesia technique that provides effective postoperative analgesia. The serratus posterior superior intercostal plane block (SPSIPB) is a recently described interfascial block with promising analgesic effects, but evidence comparing its efficacy with SAPB in breast surgery remains limited. This prospective, randomized, double-blind, single-center clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided SPSIPB and SAPB in patients undergoing modified radical mastectomy under general anesthesia. S

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients aged 18 to 65 years. * Scheduled for elective modified radical mastectomy under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I-III. * Body mass index (BMI) \<35 kg/m². * Normal coagulation profile (including INR and platelet count). * Normal liver and renal function tests. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics. * Coagulation disorders or bleeding diathesis. * Infection or inflammation at the planned block site. * ASA physical status IV or higher. * Chronic opioid use or chronic pain requiring long-term analgesic therapy. * Advanced hepatic or renal insufficiency. * Severe pulmonary disease. * Opioid use within 24 hours before surgery. * Cognitive impairment or inability to complete postoperative assessments. * Revision breast surgery. * Refusal to participate in the study.
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What it tests

  • Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
  • Ultrasound-Guided Serratus Anterior Plane Block (SAPB)
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Where

1 site
Sultan 2. Abdulhamid Han Training and Research Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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