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โ† Trials
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Perinatal Autism Genetics and Epigenetics Study

Recruitingn/aAges 0 Years - 50 YearsAllUniversity of Iowa
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In plain words

What the trial is, and whether it could suit you

The University of Iowa's Center for Disabilities and Development is researching how pregnancy, early childhood experiences, and genetic factors influence child development, with a focus on autism spectrum disorder (ASD). Pregnant women are invited to participate in a study that tracks their pregnancy and child's early development, through simple, at-home activities using a cell phone. Participants complete short questionnaires, join an online interview, and videotape their baby's play after birth. They are also sent a kit to swab their baby's mouth to collect cheek cells for genetic testing. The study will explore whether stress and early social experience lead to genetic changes associated with autism or other developmental conditions.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: A. Criteria for Pregnant Women: 1. Pregnant women in their 1st or 2nd trimester of a singleton pregnancy. 2. Age 18 to 50 years 3. Currently use a smart phone B. ASD Group at age 18 to 27 months 1. M-CHAT score \>= 4 or POSI score \>= 3 2. Child has subsequently clinically confirmed diagnosis of ASD, based on ADOS/TAP testing and/or other clinical evaluation C. Developmental Delay (DD) Group at age 18 to 27-months 1. Developmental screening score on SWYC in the "at risk" range. 2. Child has subsequently clinically confirmed developmental delay on clinical evaluation and/or self-report measure D. Typically Developing (TD) Group at age 18 to 27 months - None Exclusion Criteria: A. Criteria for Pregnant Women: 1. Non-English speaking mother 2. History of severe mental illness in the past year, resulting in inpatient admission B. All children 1. \<35 weeks gestational age at birth 2. History of serious neonatal complications requiring NICU admission for one week or more 3. Known genetic or syndromic condition (e.g. Down Syndrome, etc.) that impacts learning and brain development 4. Hearing impairment C. ASD Group at age 18 to 27 months \- None D. Developmental Delay (DD) Group at age 18 to 27 months 1. Screen positive for ASD (M-CHAT \>= 4 AND POSI \>= 3) 2. First-degree relative who has been diagnosed with ASD E. Typically Developing (TD) Group at age 18 to 27 months 1. Screen positive for ASD (M-CHAT \>= 4 AND POSI \>= 3) 2. Developmental screening/assessment score in the "at risk" range. 3. First-degree relative who has been diagnosed with ASD
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What it tests

  • Change in child's DNA methylation
  • Perinatal stress
  • Early social experience
  • Polygenic risk scores for social communication and repetitive behavior
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Where

1 site
Center fro Disabilities and Development
Iowa City, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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