Factors Affecting Clinical and Radiological Outcome in Endovascular Management of Acute Ischemic Stroke Due to Large Vessel Occlusion

Inclusion Criteria: * General Criteria (Applicable to All Time Windows) * Age ≥ 18 to 80 years old. * Acute ischemic stroke due to large vessel occlusion (LVO) presenting within 24 hours from symptom onset or last known well. Occlusion involving one of the following vessels: * internal carotid artery (ICA) * M1 segment of the middle cerebral artery (MCA) * A1 segment of the anterior cerebral artery (ACA) * P1 segment of the posterior cerebral artery (PCA) * Basilar artery (BA) * V4 segment of the vertebral artery (VA) * National Institutes of Health Stroke Scale (NIHSS) score ≥ 6. Patients Presenting Within 0-6 Hours from Symptom Onset or Last Known Well , * Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6. Patients presenting 6-24 hours from the last known well, imaging eligibility based on : * Estimated ischemic core volume \< 70 mL. * Ratio of critically hypoperfused tissue to ischemic core (mismatch ratio) ≥ 1.8. * Absolute volume of potentially salvageable tissue (Diffusion to flair mismatch volume) ≥ 15 mL. Exclusion Criteria: * • Patients with stroke resulting from etiologies other than LVO. * Individuals with a history of previous strokes. * Hemorrhagic stroke * Large established infarction (e.g., ASPECTS \< 6 for patients within the early time window or imaging findings not meeting eligibility criteria in the late window). * Patients presenting 6-24 hours from the last known well who do not meet advanced imaging selection criteria (e.g., DEFUSE 3 or DAWN eligibility criteria). * Pre-stroke disability with a modified Rankin Scale (mRS) score ≥2. * Rapid improvement in neurological status to an NIHSS \< 6 or evidence of vessel recanalization prior to randomization.