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Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction

Recruitingn/aAges 18 Years - anyAllIstituti Clinici Scientifici Maugeri SpA
NCT07741305 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will compare two ultrasound techniques, 2D and 3D speckle-tracking echocardiography, for measuring how well the heart muscle contracts in patients with heart failure and reduced pumping function. While 2D global longitudinal strain (GLS) is widely used and has proven value in predicting outcomes, 3D GLS may provide a more complete assessment of heart function. Researchers will enroll 419 patients from seven cardiac rehabilitation hospitals in Italy and analyze heart ultrasound images using standardized equipment and software. The study will assess how closely 2D and 3D GLS measurements agree, identify factors that influence any differences, and determine whether 3D GLS better predicts the risk of death than 2D GLS.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Left ventricular ejection fraction (LVEF) ≤ 49%; * Echocardiographic image quality judged to be at least adequate according to a four-point visual image quality scale (good, adequate, poor, or inadequate) Exclusion Criteria: * Inability to maintain the correct position for acquiring echocardiographic images; * Arrhythmias that make multi-beat acquisition impossible (if required), such as frequent extrasystoles (supraventricular or ventricular) and atrial fibrillation; * Failure to visualize more than 2 segments of the left ventricle (LV), or inability to assess more than 3 segments during 3D GLS analysis; * Failure to sign the informed consent form and inability of the participant to understand the objectives of the study
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What it tests

  • Not listed
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Where

5 sites
ICS Maugeri - Istituto di Bari
Bari, Italy
ICS Maugeri - Istituto di Milano
Milan, Italy
ICS Maugeri - Istituto di Pavia
Pavia, Italy
ICS Maugeri Torino
Torino, Italy
ICS Maugeri - Istituto di Veruno
Veruno, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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