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Oxytocin in Postmenopausal Women

Recruitingn/aAges 18 Years - anyFemaleUniversity Hospital, Basel, Switzerland
NCT07742124 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women. Using repeated measurements of neurophysin-I (NP-I, equimolar surrogate marker of oxytocin) across defined physiological time points, this study investigates oxytocin system regulation under cyclic and non-cyclic hormonal conditions. The primary hypothesis is that cumulative NP-I release, expressed as the area under the curve (AUC) is lower in the postmenopausal group compared to the premenopausal group.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female sex at birth * Age ≥18 years Premenopausal group: • Premenopausal women aged 18-35 years with regular menstrual cycles (21-35 days) for ≥3 months prior to study entry Postmenopausal group: • Postmenopausal women ≥2 years of postmenopause (i.e. 3 years since last menstrual period (LMP), with menopause defined as ≥ 12 months of amenorrhea) Exclusion Criteria: * Pregnancy or breastfeeding * Use of hormonal contraception or hormone replacement therapy within the last 3 months * Known endocrine disorders affecting the hypothalamic-pituitary-gonadal axis * Use of medications * Severe depression (BDI score \> 28 points), any other severe psychiatric illness or acute medical disease * Inability to comply with study procedures * Participation in a trial with investigational drugs within the last 30 days
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What it tests

  • Repeated assessments
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Where

1 site
University Hospital Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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