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Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery

RecruitingNAAges 18 Years - anyAllFinal International University
NCT07742826 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18 years and older. * Patients with good general health * Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable) * Patients willing and able to attend all postoperative follow-up visits Exclusion Criteria: * Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency). * Pregnant or breastfeeding women. * Patients with acute infection, abscess, or pericoronitis at the surgical site. * Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications. * Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates. * Patients with bleeding disorders. * Patients with previous radiotherapy to the head and neck region. * Patients unable or unwilling to comply with the study protocol or attend follow-up visits.
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What it tests

  • Platelet-rich fibrin (PRF)
  • Dexamethasone
  • Amoxicillin/Clavulanic Acid
  • Paracetamol
  • Chlorhexidine
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Where

1 site
Final International University Faculty of Dentistry
Nicosia, Cyprus
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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