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Olanzapine Based Dexamethasone-sparing Regimen for Breast Cancer Patients With Metabolic-risk Factors

RecruitingNAAges 18 Years - 70 YearsFemaleAlexandria University
NCT07743827 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of THE STUDY to determine whether an olanzapine-based dexamethasone-sparing antiemetic regimen is non-inferior to the standard dexamethasone-containing regimen in preventing delayed-phase Chemotherapy-induced nausea and vomiting while reducing metabolic toxicity in breast cancer patients with metabolic risk factors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients ≥18 years. * Stage I-III breast cancer. * Scheduled to receive AC chemotherapy. * Presence of metabolic risk factors (diabetes, prediabetes, obesity, metabolic syndrome). * ECOG performance status ≤2. Exclusion Criteria: * Recent systemic corticosteroid use. * Active nausea or vomiting before chemotherapy. * Severe renal or hepatic impairment. * Uncontrolled diabetes or hypertension. * Psychiatric illness affecting adherence. * Pregnancy or lactation. * Active infections or inflammatory diseases. * Participation in another clinical trial
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What it tests

  • Pantoprazole
  • olanzapine
  • Dexamethasone
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Where

1 site
Alexandria Main University Hospital
Alexandria, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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