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Vitamin D Status and Clinical Outcomes in Locally Advanced Cervical Cancer

Recruitingn/aAges 18 Years - 80 YearsFemaleUniversity of Kragujevac
NCT07743918 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background. Definitive chemoradiotherapy represents the standard therapeutic approach for the management of locally advanced cervical cancer. Vitamin D plays an important role in the regulation of cellular growth and differentiation, immune system function, and the modulation of inflammatory processes. Hypovitaminosis D may be associated with the development of cervical cancer, whereas its impact on the effects of oncological treatment remains insufficiently elucidated. The aim of this study is to investigate the predictive significance of vitamin D in patients with locally advanced cervical cancer treated with definitive chemoradiotherapy. Methods. This study is designed as a clinical, observational, prospective cohort study. Patients with locally advanced cervical cancer undergoing definitive chemoradiotherapy at the Clinic for Radiation Oncology, University Clinical Center Kragujevac

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients aged 18 to 80 years. * Histopathologically confirmed cervical cancer. * Locally advanced disease, FIGO 2018 stage IIB to IVA. * Eastern Cooperative Oncology Group performance status 0-1. * Planned treatment with definitive concurrent chemoradiotherapy. * Signed informed consent. * Ability to comply with study procedures and follow-up visits. Exclusion Criteria: * Age under 18 years. * Pregnancy or lactation. * Previous or synchronous diagnosis of another pelvic or abdominal malignancy. * Previous chemotherapy. * Previous radiotherapy. * Previous treatment with immune checkpoint inhibitors. * Current or recent vitamin D supplementation. * Interrupted oncological treatment. * Failure to attend scheduled follow-up visits. * Incomplete medical documentation.
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What it tests

  • Pretreatment Vitamin D Assessment in Serum and Cervical Lavage Fluid
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Where

1 site
University Clinical Center Kragujevac
Kragujevac, Serbia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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