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Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis

RecruitingEARLY Phase 1Ages any - anyAllDoaa Atta Aid
NCT07746206 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus hyaluronic acid as an adjunct to non surgical periodontal therapy in stage Ⅲ periodontitis patients. This will be done by: 1. Clinical assessment. 2. Biochemical analysis. - Dose the topical application of insulin or hyaluronic acid as an adjunct to non-surgical periodontal therapy improves periodontal condition in stage Ⅲ periodontitis patients? PICO P (Population): patients with stage Ⅲ periodontitis. I (Intervention): non surgical periodontal therapy (SRP) with topical application using insulin or hyaluronic acid in periodontal pockets. C (Comparison): topical application of insulin versus hyaluronic acid and SRP alone in periodontal pocket. O (Outcome): primar

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📋 Eligibility rules (as published)
Inclusion Criteria: * All selected patients are free from systemic illness as evaluated according to dental modification of the Cornell medical index. * Should be diagnosed as having periodontitis. * Not received any type of periodontal treatment in the past 6 months prior to examination. * Should be cooperative, motivated, and willing to follow our treatment protocol and follow up visits. * Not received antibiotics or anti-inflammatory therapy in the 6 months prior to examination. Exclusion Criteria: * Antibiotic therapy in the preceding 6 months or during study participation. * History of insulin dependent diabetes and thyroid disease. * Pregnancy, smoking, chronic diseases such as diabetes mellitus or rheumatoid arthritis, and allergy to ingredients in the drug. * Poor oral hygiene compliance or inability to adhere to the clinical protocol.
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What it tests

  • Insulin
  • Hyaluronic acid gel
  • mechanical debridement
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Where

2 sites
Alazhar university
Cairo, Egypt
Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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