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EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT

Recruitingn/aAges 18 Years - 60 YearsAllIstanbul University - Cerrahpasa
NCT07748091 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant treatments, using microstate analysis derived from resting-state electroencephalography (EEG) recordings. Within this scope, EEG recordings obtained before and after ECT will be compared to determine the relationships between changes in microstate parameters and inflammatory marker levels, clinical variables, and psychometric scale scores reflecting clinical improvement. Peripheral blood samples collected from the same patient group will be analyzed for complete blood count parameters as well as levels of interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necros

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📋 Eligibility rules (as published)
Inclusion Criteria: Patient Group * Age 18-60 years * Diagnosis of Major Depressive Disorder, current major depressive episode, according to DSM-5 criteria. * Clinical indication for electroconvulsive therapy (ECT). * Ability to provide written informed consent. * Willingness to participate in the study. Healthy Control Group: * Age ≥55 years. * No current psychiatric disorder. * No known neurological disorder. * Good general physical health. * No current use of medications known to affect EEG activity or inflammatory biomarkers significantly. * Ability to provide written informed consent. * Willingness to participate in the study. Exclusion Criteria: * Primary neurological disorders (e.g., dementia or traumatic brain injury). * Schizophrenia or other psychotic disorders. * Bipolar disorder diagnosis, * Intracranial space-occupying lesions. * Increased intracranial pressure. * Myocardial infarction within the previous 3 months. * Cerebrovascular disease within the previous month. * Unstable cerebral aneurysm. * Pheochromocytoma. * Electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) within the previous month. * Cognitive impairment severe enough to prevent adequate cooperation during EEG recording. * Current alcohol or substance use disorder. * Active infectious disease. * Autoimmune or chronic inflammatory disorders. * Current use of systemic corticosteroids, immunosuppressive agents, or other medications known to affect inflammatory biomarkers significantly.
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What it tests

  • Electroconvulsive Therapy
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Where

1 site
İstanbul University- Cerrahpasa, Cerrahpasa Medicine Faculty, Psychiatry Department
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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