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Pneumococcal Carriage Duration

Recruitingn/aAges 28 Days - 48 MonthsAllUniversity of Central Florida
NCT07748832 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Are older than 28 days and under 4 years of age at the time of enrollment. * Have a parent or legal guardian who: 1. Provides written informed consent. 2. Is able to read and speak English or Spanish. 3. Agrees to comply with all study procedures, including completion of questionnaires and biweekly oropharyngeal (OP) swab collections from the child for a period of 12 months. Exclusion Criteria: * History of chronic medical conditions or immunocompromising conditions that may influence pneumococcal carriage or study participation, such as: * cystic fibrosis * cerebral palsy * neuromuscular disorders * congenital heart disease * known congenital or acquired immunodeficiencies * sickle cell disease * undergoing immunosuppressive therapy (e.g., systemic corticosteroids ≥2 mg/kg/day for ≥14 days, chemotherapy, biologics)
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What it tests

  • Oropharyngeal (OP) swab
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Where

1 site
University of Central Florida
Orlando, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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