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Stroke Volume-based Fluid Resuscitation in AP

RecruitingNAAges 18 Years - 75 YearsAllUniversity of Southern California
NCT07756476 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients between the age of 18-75 * Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment Exclusion Criteria: * Patients with the inability to preform a straight leg raise (i.e amputation) * Patients with high risk of adverse event related to fluid resuscitation * NYHA Class \>= II Heart Failure * Child's B and C Cirrhosis * Dialysis Requirement * Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites * Ages \<18 years old * Pregnant * Incarcerated * Unable to provide informed consent
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What it tests

  • Lactated Ringer's
  • Lactated Ringers Stroke Volume Based Dosing
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Where

2 sites
University of Southern California
Los Angeles, United States
Ohio State University
Columbus, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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