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Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal Treatment

RecruitingEARLY Phase 1Ages 18 Years - 60 YearsAllDow University of Health Sciences
NCT07759349 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized control trial will be planned according to PRIRATE 2020 guideline for reporting randomized trials in Endodontics. The protocol of this study will be multiple parallel arm, single blinded, randomized single centered clinical trial (allocation ratio 1:1) The study will be conducted after taking the approval from the Institutional review board (IRB), Dow University of Health Sciences (Karachi). The participants will be selected according to the inclusion and exclusion criteria and on the basis of digital peri-apical radiograph and pulp sensibility test. After taking consent (Annexure form B) from patient, cold test will be performed by applying, a cotton pellet wetted with cold spray (Endodontia) to the middle third of the buccal surface of the affected tooth. Then results of electrical test will be assessed by using a digital electric pulp tester (EPT) \[Parkell (Sybron End

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📋 Eligibility rules (as published)
INCLUSION CRITERIA * Both sex * Healthy ( American Society of Anesthesiologists class 1) * Age 18-60 years * Pulpal diagnosis: Symptomatic irreversible pulpitis in mandibular premolar (single canal) periapical diagnosis: symptomatic apical periodontitis * The ability of participants to understand a pain scale (VAS) Exclusion Criteria: * Pregnant females * Systemic disease and immune deficiency * Taken analgesics 24 hours, prior to treatment * Non-vital, previously initiated, previously treated teeth * Radiographic evidence of peri-radicular pathosis * Teeth with cracks, fractures and history of trauma * Developmental anomalies and immature apices * Allergic to local anesthetic solution or any experimental drugs * Patient being unable to provide informed consent.
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What it tests

  • Acetaminophen
  • NSAID
  • trypsin-chymotrypsin
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Where

1 site
Dow University of Health Sciences
Karachi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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