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Using Non-Invasive Mapping To Eliminate Structural Heart Disease Ventricular Tachycardia

RecruitingNAAges 18 Years - anyAllUniversity of Warwick
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In plain words

What the trial is, and whether it could suit you

Ventricular tachycardia (VT) is an abnormal and dangerous heart rhythm affecting the lower chambers of the heart (the ventricles). Patients with structural heart disease caused by previous heart attacks are at an increased risk of developing VT. Current guidelines recommend that patients who develop this abnormal heart rhythm are considered for invasive catheter ablation (ICA). This is an invasive procedure where specialised catheters and a 3D electro anatomical mapping (EAM) system are used to identify the region of the heart responsible for the VT, which is then treated by tissue heating or freezing (ablation). Although significant improvements have been made in both mapping and ablation technologies, these procedures remain technically challenging and time consuming. View into ventricular onset (VIVO, Catheter Precision) is a non-invasive, mapping system already being used within the

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * โ‰ฅ18 years old * Patient with the following: * Evidence of post-myocardial infarction\* structural heart disease. * Cardiac CT and/or cardiac MRI scan performed within 6 months. * ICD/CRTD implantation. * Device therapy for VT: at least 1 appropriate ICD shock or 3 ATP episodes within a 6-month period. * Suitable candidate for VT ablation as per NHS standard of care. * Patient agrees to comply with study procedures and be available for routine follow up visits for at least 6 months after enrolment. Exclusion Criteria: * Lacks capacity to provide informed consent. * Presence of intramural thrombus, tumour or abnormality that precludes vascular access, catheter introduction or manipulations. * Coagulopathy, bleeding diathesis or suspected pro-coagulant state. * Sepsis, active systemic infection or fever (\>100.5 F/38 C) within a week prior to the ablation procedure. * Renal failure requiring dialysis or renal compromise that in the investigator's judgement would increase risk to the patient or deem the patient inappropriate to participate in the study. * Known allergies or intolerance to AADs to be used to treat PVCs. * Known allergy for contrast. * Female patients who are pregnant or breast feeding. * Enrolment in a concurrent interventional clinical study that in the judgement of the investigator would increase risk to the patient or deem them inappropriate to participate in this study. * Other conditions that may prevent patients from adhering to the study protocol, in the opinion of the investigator.
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What it tests

  • VIVO-assisted mapping
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Where

3 sites
Royal Sussex County Hospital
Brighton, United Kingdom
University Hospitals Coventry and Warwickshire
Coventry, United Kingdom
The James Cook University Hospital
Middlesbrough, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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