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Effects Of Propofol And Sevoflurane On Plasma Mirna Levels İn Living Kidney Donors

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Gaziantep
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In plain words

What the trial is, and whether it could suit you

Surgical interventions and associated tissue trauma induce a complex systemic inflammatory stress response characterized by the activation of neuroendocrine, metabolic, and immunological systems. Donor nephrectomy operations performed in living kidney donors are among the unique clinical models where these inflammatory cascades and cellular stress pathways are most intensely observed, due to major surgical trauma and unavoidable ischemia-reperfusion injury during organ clamping. Recent studies have demonstrated that microRNAs (miRNAs), which epigenetically regulate gene expression at the post-transcriptional level, serve as key determinants in perioperative medicine regarding immune response, resolution of inflammation, and cellular adaptation processes . Among our target molecules, miR-146a acts as a dominant, negative regulator (brake mechanism) of the innate immune response , while mi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Living kidney donors aged between 18 and 65 years. * Scheduled for an elective donor nephrectomy operation under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I or II. * Body Mass Index (BMI) strictly less than 35 kg/m². * Provided written informed voluntary consent to participate in the study. Exclusion Criteria: * Known history or clinical diagnosis of malignancy or Diabetes Mellitus (DM). * Active or history of chronic systemic inflammatory or autoimmune diseases. * Chronic use of analgesics or documented history of substance abuse. * Known hypersensitivity or allergic reaction to any of the anesthetic agents used in the study (Sevoflurane or Propofol). * Diagnosed with dementia, severe cognitive impairment, or any significant psychiatric disorder.
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What it tests

  • Sevoflurane
  • propofol
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Where

1 site
Gaziantep University Sahinbey Research and Application Hospital
Gaziantep, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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