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Colchicine And Dialysis Patients; a Feasibility Study

RecruitingNAAges 18 Years - anyAllKing's College London
NCT07762807 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Colchicine is an inexpensive drug that has been available for decades. Trials, which excluded patients with kidney disease, showed that colchicine decreased the number of heart attacks and strokes. The investigators cannot be sure if these results will apply to dialysis patients and a clinical trial exploring the effect of colchicine on heart attacks and strokes specifically in dialysis patients is needed. Colchicine may also be beneficial for dialysis patients as it may help arteriovenous fistulas to last longer. An arteriovenous fistula is a connection made between an artery and a vein in the arm, allowing for access to a person's bloodstream as part of dialysis. Sometimes, these connections can get too narrow in some parts, stopping them from working properly. These narrowings can be treated with a balloon inserted into the vein with the help of an x-ray. Balloons coated with a drug c

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Anyone who is undergoing haemodialysis. 2. Aged 18 or over 3. Able to give informed consent Exclusion Criteria: 1. Already taking colchicine for a clinical indication. 2. Taking a drug known to increase colchicine levels. 3. Has a previously documented intolerance of or allergy to colchicine 4. Has a history of chronic liver disease, or abnormal liver function (i.e. ALT \> 1.5 x upper limit of normal). Patients with a history of hepatitis are eligible provided these limits are not exceeded.
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What it tests

  • Colchicine 0.5 mg
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Where

1 site
Guy's and St Thomas' NHS Trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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