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โ† Trials
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Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery

Recruitingn/aAges 18 Years - anyAllUniversity of Chicago
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In plain words

What the trial is, and whether it could suit you

This prospective observational study will investigate the relationship between the gut microbiome and adverse effects following stereotactic radiosurgery (SRS). Patients undergoing SRS as part of their standard clinical care will provide blood and stool samples before treatment and during follow-up. Samples will be analyzed to characterize fecal and blood metabolomic profiles and changes in the gut microbiome over time. The study has two primary objectives: to determine how stereotactic radiosurgery affects the gut microbiome and associated metabolomic profiles, and to evaluate whether microbiome- and metabolite-associated features are related to the development of adverse effects following SRS. Clinical data and standard-of-care neuroimaging will be collected longitudinally to identify outcomes including radiation necrosis and other adverse radiation effects. Biological profiles from p

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Admitted to the University of Chicago Medical Center * Receiving stereotactic radiosurgery as standard of care for their presumed diagnosis * Able to provide informed consent Exclusion Criteria: * Anticipated survival of less than 6 months * Known or suspected infectious colitis within the month prior to enrollment * Rectal disease that prevents fecal sampling * Foreseeable inability to complete the study
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What it tests

  • Not listed
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Where

1 site
University of Chicago
Chicago, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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