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Real-time Opioid Study

RecruitingNAAges 18 Years - 50 YearsAllYale University
NCT07768007 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This feasibility study collects initial data on the use of an fMRI neurofeedback protocol for treating anhedonia in methadone-treated individuals with opioid use disorder (OUD). The intervention tested has previously been shown to reduce anhedonia in individuals with depression and this study is collecting first-in-human data in an OUD population. Investigators will assess tolerability of the intervention and collect preliminary data from 2-3 subjects monitoring changes in anhedonia, non-substance-related autobiographical memory recall, and meaning in life.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≥3 months of methadone treatment for OUD * Presence of anhedonia, as assessed via SHAPS * Room for improvement in specific autobiographical memory recall, as assessed via AMT Exclusion Criteria: * Failure to pass an MRI screening * Women who are pregnant * Psychosis, as assessed via Yale PRIME Early Psychosis Screening Test * Serious suicidal ideation * Serious medical condition * Legally blind
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What it tests

  • real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback
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Where

1 site
APT Foundation
New Haven, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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